T antigen - traducción al árabe
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T antigen - traducción al árabe

PROTO-ONCOGENE DERIVED FROM POLYOMAVIRUS SV40
SV40 TAg; T-antigen; SV40 Large T-antigen; T antigen; SV40 large T-antigen; Simian virus 40 large T-antigen; SV40T

T antigen         
‎ المُسْتَضِدُّ T:مُسْتَضِدٌّ وَرَمِيّ‎
antigenic         
  • An illustration that shows how antigens induce the [[immune system]] response by interacting with an [[antibody]] that matches the [[molecular structure]] of an antigen
MOLECULE CAPABLE OF INDUCING AN IMMUNE RESPONSE (TO PRODUCE AN ANTIBODY) IN THE HOST ORGANISM
Antigens; Antigenic; Tolerogen; Receptors, antigen; Exogenous antigen; Native ag; Antigen nativity; Native antigen; Auto-antigen; Antibody generator; Antigene
‎ مُسْتَضِدِّيّ‎
ANTIGEN         
  • An illustration that shows how antigens induce the [[immune system]] response by interacting with an [[antibody]] that matches the [[molecular structure]] of an antigen
MOLECULE CAPABLE OF INDUCING AN IMMUNE RESPONSE (TO PRODUCE AN ANTIBODY) IN THE HOST ORGANISM
Antigens; Antigenic; Tolerogen; Receptors, antigen; Exogenous antigen; Native ag; Antigen nativity; Native antigen; Auto-antigen; Antibody generator; Antigene

ألاسم

مولد المضاد

Definición

antigen
¦ noun a substance which the body recognizes as alien and which induces an immune response. Compare with antibody.
Derivatives
antigenic adjective
Origin
early 20th cent.: via Ger. from Fr. antigene (see anti-, -gen).

Wikipedia

SV40 large T antigen

SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function. Similar proteins from related viruses are known as large tumor antigen in general.

TAg is a product of an early gene transcribed during viral infection by SV40, and is involved in viral genome replication and regulation of host cell cycle. SV40 is a double-stranded, circular DNA virus belonging to the Polyomaviridae (earlier Papovavirus) family, Orthopolyomavirus genus. Polyomaviruses infect a wide variety of vertebrates and cause solid tumours at multiple sites. SV40 was isolated by Sweet and Maurice Hilleman in 1960 in primary monkey kidney cell cultures being used to grow Sabin OPV.